Transient severe brain stem depression during intraarterial papaverine infusion for cerebral vasospasm.
نویسندگان
چکیده
A 63-year-old woman had severe, symptomatic cerebral vasospasm secondary to subarachnoid hemorrhage. We initiated simultaneous infusions of papaverine into her left vertebral and left internal carotid arteries. Twenty-five minutes after the infusions had begun, the patient had a transient reaction of respiratory arrest followed by rapid, progressive loss of brain stem function.
منابع مشابه
In vitro evaluation of papaverine hydrochloride incompatibilities: a simulation of intraarterial infusion for cerebral vasospasm.
PURPOSE To elucidate, in light of reports of complications associated with intraarterial infusion of papaverine hydrochloride, the known propensity of papaverine hydrochloride to form precipitate in combination with other solutions or pharmaceuticals. METHODS Initially simulating a situation experienced during an intraarterial papaverine infusion for cerebral vasospasm, we mixed various conce...
متن کاملTransient neurologic events associated with intraarterial papaverine infusion for subarachnoid hemorrhage-induced vasospasm.
This report describes three patients who experienced transient neurologic events associated with intraarterial papaverine infusion in the vertebrobasilar system. Two of these involved respiratory depression and underscore the need for careful monitoring and, when required, cardiopulmonary support.
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PURPOSE To determine the appropriate concentration of papaverine for therapeutic intraarterial infusion against cerebral vasospasm. METHODS We investigated histopathologic changes in cerebral arteries and brain tissue of normal Wistar rats that had received infusions of papaverine via the carotid artery. Rats were infused with 0.20 mL papaverine (concentration, 0.4% to 4.0%) via the internal ...
متن کاملIntracranial pressure monitoring during intraarterial papaverine infusion for cerebral vasospasm.
PURPOSE Intraarterial papaverine infusions are performed to reverse cerebral arterial vasospasm resulting from subarachnoid hemorrhage, but such infusions may lead to increases in intracranial pressure (ICP). This study was undertaken to determine when ICP monitoring is indicated during papaverine treatment. METHODS Seventy-eight vessels were treated in 51 sessions in 28 patients with symptom...
متن کاملIntraarterial papaverine for the treatment of vasospasm.
The authors describe the use of intraarterial papaverine to treat vasospasm following subarachnoid hemorrhage. Two cases are reported: a 40-year-old woman with a posterior communicating artery aneurysm and a 67-year-old man with a posterior cerebral artery aneurysm. Both patients developed symptomatic, angiographically demonstrated vasospasm that responded to papaverine infusion.
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ورودعنوان ژورنال:
- AJNR. American journal of neuroradiology
دوره 15 4 شماره
صفحات -
تاریخ انتشار 1994